Scientists still don’t know exactly what causes Alzheimer’s disease, but there’s a general consensus that clumps of certain proteins— beta-amyloid and tau—in the brain are key indicators.
Edward Anderton, PhD, a postdoctoral researcher at The Buck Institute for Research on Aging in California, explained to Medical News Today that the common thread in neurodegenerative diseases of aging is the buildup of large protein clumps, known as insoluble protein aggregates. In Alzheimer’s, beta-amyloid proteins form aggregates called plaques, which are closely linked to areas of neuronal death and brain inflammation that drive the disease.
However, he pointed out that these plaques contain hundreds of other proteins that have mostly been overlooked until now.
That’s why he and other researchers at The Buck Institute decided to study how the general accumulation of insoluble proteins might speed up Alzheimer’s. In their research study reported in GeroScience using a worm model, they discovered that both the natural aging process and beta-amyloid cause other proteins to become insoluble.
They then used a compound to improve mitochondrial health in these insoluble proteins, which delayed the toxic effects of beta-amyloid.
Mitochondria, often called the cell’s powerhouses, have become a key focus in Alzheimer’s research. Scientists are investigating whether “repairing” aging mitochondria can help maintain brain health.
Imagine if you had a key that got bent and no longer fit into its lock—that’s similar to what happens when proteins lose their shape. These misshapen proteins start sticking together and form insoluble protein aggregates. Proteins can lose their shape due to various factors like stress, aging, Spike Protein, or damage.
Our cells have evolved ways to either refold the proteins into the correct shape or degrade them when they’re too damaged to be refolded.
In conditions such as Alzheimer’s disease, the brain doesn’t correctly dispose of these proteins. It’s well established that Alzheimer’s disease patients’ brains accumulate protein aggregates.
Can Boosting Mitochondrial Health Prevent Toxic Aggregate Formation?
That’s the question researchers are trying to answer. They wanted to see if they could counteract how beta-amyloid promotes protein insolubility.
Since many mitochondrial proteins become insoluble during natural aging and under the influence of beta-amyloid, they thought that improving the quality of these proteins might mitigate some of beta-amyloid’s harmful effects.
Mitochondria contain a specialized energy-producing complex of proteins called the electron transport chain, which is the primary way our cells use food to produce energy, according to their research. They found that the proteins of the electron transport chain became insoluble when exposed to beta-amyloid.
It has been known for some time that mitochondria can be negatively impacted by beta-amyloid, but we show that this is likely due to protein insolubility. Fortunately, cells have a way to recycle damaged mitochondria through a process called mitophagy. Their lab and others are studying a small molecule that boosts mitophagy to rejuvenate mitochondria.
How to Boost Mitochondria and Prevent Alzheimer’s
We have been talking about the fact that Alzheimer’s is also referred to as type 3 diabetes and linked to insulin resistance. This means it is somewhat in your control and caused by lifestyle choices. We’ve also talked about how Alzheimer’s risk can be increased due to genetics when you have two copies of the APOE4 Gene like I do. This is another study giving you hope where you are in control.
Whether it is weight loss, reversing heart disease, fatty liver, wrinkles or hair loss, it comes down to ATP and mitochondrial health. nsulin resistance lowers ATP, which is your cellular energy, and lowers your mitochondrial health. This is why you need to address your diet, supplements, exercise, sleep, and stress— all things that can degrade or enhance your mitochondria!
Remember,
Insulin resistance in the brain leads to Alzheimer’s
Insulin resistance in the liver leads to diabetes
Insulin resistance in the ovaries leads to PCOS
Insulin resistance at the heart leads to heart disease.
Insulin resistance lowers ATP and mitochondrial health.
Supplements To Enhance Mitochondrial Health and Prevent Alzheimer’s
Accelerated Cogniblast® Nootropic
Accelerated Cogniblast® is a unique nootropic supplement combining traditional Ayurvedic herbs known for brain health with advanced nutraceuticals. This blend is designed to:
- Enhance mood
- Boost focus
- Increase ATP production
- Reduce anxiety
- Heighten motivation
- Decrease the risk of Alzheimer’s and dementia
- Neutralize harmful free radicals
- Reduce inflammation
- Support liver, lung, kidney, and overall organ health
- Improve circulation
- Lower stress levels
- Optimize energy
Additionally, Accelerated Cogniblast® is infused with proprietary scalar frequencies to:
- Release emotional and physical shock from the body
- Boost brain health
- Enhance memory
- Detoxify halogen toxins from the pineal and pituitary glands
- Decalcify the pineal, pituitary, and hypothalamus
- Balance both hemispheres of the brain
Acceleradine® Iodine
Iodine deficiency is a key factor in issues like depression, brain fog, and overall brain health. It also significantly increases ATP levels by 18 times, boosting cellular energy, mitochondrial health, metabolism, calorie burn, brain function, physical performance, wound healing, fat burning, and healthy apoptosis (natural elimination of diseased cells).
Iodine detoxifies the brain from harmful toxins like fluoride, helping you think more clearly, connect with your higher self, and prevent brain deterioration. It also boosts metabolism and supports thyroid health, providing both physical and mental energy to tackle daily challenges. Research links poor thyroid function to higher rates of depression and mental illness.
Iodine’s antimicrobial properties help fight off fungi, parasites, viruses, and bacteria, keeping your brain functioning optimally.
Acceleradine® iodine stands out as the only monatomic iodine achieving 100% absorption, compared to the typical 10-20% absorption of other iodine supplements. Enhanced with scalar frequencies, it helps detoxify the brain and body from radiation, heavy metals, fluoride, bromide, and chlorine, all of which can impair brain function.
Accelerated Methylene Blue
Methylene blue is gaining attention for its wide range of benefits:
- Antioxidant Properties: Fights oxidative stress, which is linked to aging and chronic diseases.
- Neuroprotective Effects: May protect the brain and is being studied for its potential to treat neurodegenerative diseases like Alzheimer’s and Parkinson’s.
- Electron Carrier: Effective against conditions like malaria and methemoglobinemia, it helps the brain by stimulating oxygen use and reducing anaerobic glycolysis in toxic situations.
- Reduction of Reactive Oxygen Species (ROS): Acts as an electron carrier to reduce ROS production, protecting cells from challenges like glutamate blockage. It also helps maintain mitochondrial membrane potential and guards against neurotoxicity.
- Relevance to Neurodegenerative Conditions: These properties are significant for diseases like Alzheimer’s, Parkinson’s, and stroke. Unlike antipsychotic drugs, methylene blue functions as a mitochondria-specific antioxidant.
- Potential for Brain Damage Prevention: May help manage brain damage linked to tumors and treatments like ifosfamide.
- Enhancement of Mitochondrial Function: Interacts with mitochondria to boost their function, improving energy production, reducing mitochondrial dysfunction and oxidative damage, and preventing ATP decline.
- Antimicrobial Properties: Effective against various bacteria, viruses, and fungi.
- Cognitive Enhancement: Some evidence suggests it can enhance cognitive function and memory.
- Treatment for Methemoglobinemia: Used to treat this condition where there’s too much methemoglobin in the blood.
- Antidepressant Properties: May have antidepressant effects by increasing serotonin levels.
- Increase Nitric Oxide: Might increase nitric oxide, a vasodilator that promotes better blood flow.
Accelerated Methylene Blue™ Supplement is crafted with John Ellis Distilled Water and filtered through the Grander water system, ensuring 100% pure ingredients.
- John Ellis Distilled Water: Produced using patented distillers that maintain a bond angle above 108 degrees, effectively eliminating toxins by neutralizing pathogens. Its unique hydrogen bond angle allows it to kill pathogens through frothing, concentrated heat, and ultraviolet energy.
- GRANDER® Water System: Restores water to its original structure, enhancing its energetic properties and biological benefits. This system counteracts the negative effects of unhealthy electromagnetic fields, improving water quality and its benefits for living systems. It reduces the need for detergents and chemicals to maintain water quality, reversing the negative information left by pollutants and renewing the water’s internal energetic qualities.
Lifestyle Habits to Prevent Alzheimer’s and Accelerated Aging
Stop Eating Sugar, Carbs, and Processed Foods
Cutting out sugar, carbs, processed vegetable oils, and processed foods can make a huge difference. These foods cause gut inflammation, mess with your nutrient absorption, and spike your blood sugar levels. Inflammatory foods like these can lead to insulin resistance and leaky gut, major culprits behind anxiety, depression, and cognitive decline.
Focus on Eating Wild Animal Protein
Make wild animal proteins a priority. Bison, lamb, deer, elk, wild fish, and organic eggs are packed with essential nutrients that support healthy neurotransmitter and hormone production and keep your metabolism humming. Skip the poultry and conventional beef—they’re full of inflammatory fats and amyloid proteins that can harm your gut and brain, potentially paving the way for Alzheimer’s and dementia.
Sleep 7-8 Hours Every Night
Don’t skimp on sleep. Getting 7-8 hours every night is vital for both your body and brain to recover. Sleep reduces inflammation and allows your body to perform essential maintenance work.
Exercise
Get moving! Exercise boosts your mood by increasing endorphins and Brain-Derived Neurotrophic Factor (BDNF), which can help with depression and spark creativity. Aim for two sessions of High-Intensity Interval Training (HIIT) each week, and mix in some endurance and weight training for overall health benefits.
Sara Banta
Sara Banta is a Stanford University Graduate with a Degree in Economics and Psychology, and a certified Natural Supplement Expert & Graduate of the Institute for Integrative Nutrition. Sara is the Founder of Accelerated Health Products and host of the health & wellness podcast, Accelerated Health Radio.
