Histamine Intolerance: How To Lower Histamine Levels Naturally

by Sara Banta | Jan 25, 2024 | AHP News, Histamines


Due to the spike protein and various environmental factors, more people than ever are suffering from histamine intolerance and don’t know it. Unfortunately, many health practitioners aren’t connecting the dots to the new factors that trigger a histamine response. In this article, I talk about how to lower histamine levels naturally, but first of all, let’s explore histamine intolerance and how it impacts our health.

What Are Histamines?

Histamines are biogenic amines (a type of organic compound) that serve various functions in the body. They are involved in several physiological processes, including our immune response, stomach acid regulation, and brain neurotransmission. Histamines are produced and stored in certain types of white blood cells, called mast cells and basophils, as well as in the cells of the stomach lining.

The primary functions of histamines in the body include:

    • Immune Response Histamines play a key role in the body’s immune system. When the immune system encounters a harmful substance (such as an allergen or pathogen), mast cells and basophils release histamines as part of the inflammatory response. This causes blood vessels to dilate, allowing white blood cells to reach the affected area and defend against the threat.
    • Stomach Acid Regulation In the stomach, histamines are involved in the regulation of gastric acid secretion. They bind to specific receptors on the cells of the stomach lining, and stimulate the production of stomach acid (gastric acid), aiding digestion.
    • Neurotransmission In the central nervous system, histamines act as neurotransmitters. They play a role in wakefulness, alertness, and the sleep-wake cycle. Histaminergic neurons are found in the brain and play an important role in maintaining cognitive function and regulating sleep.
    • Allergic Reactions Histamines are responsible for the classic symptoms of an allergic reaction, such as sneezing, itching, hives, and nasal congestion. When the body mistakenly identifies a harmless substance (allergen) as a threat, it releases histamines, causing these allergic symptoms.

What is Histamine Intolerance?

Histamine intolerance is a condition in which the body is unable to properly metabolize histamine, a naturally occurring compound involved in several bodily functions. When histamine builds up in the body due to inefficient processing, it can lead to various symptoms and discomfort. Some common symptoms of histamine intolerance may include:

    • Headaches Recurring headaches or migraines.
    • Digestive Issues Abdominal pain, diarrhea, or other gastrointestinal problems.
    • Skin Reactions Hives, itching, or rashes.
    • Nasal and Respiratory Symptoms Congestion, sneezing, runny nose, and difficulty breathing.
    • Fatigue Unexplained fatigue or drowsiness.
    • Flushing Redness or flushing of the skin.
    • Irregular Heartbeat Rapid or irregular heartbeats.

Histamine intolerance is often linked to a deficiency in an enzyme called diamine oxidase (DAO) or histamine-N-methyltransferase (HNMT), which are responsible for breaking down histamine in the body. Without proper histamine metabolism, symptoms can occur.

Histamine intolerance can manifest with a wide range of symptoms, which can vary from person to person. Common symptoms of histamine intolerance include:

Gastrointestinal Symptoms:

Skin Symptoms:

    • Hives (urticaria)
    • Itching
    • Redness (flushing)Eczema or dermatitis

Respiratory Symptoms:

    • Runny or congested nose
    • Sneezing
    • Coughing
    • Shortness of breath
    • Wheezing

Headache and Migraine:

    • Recurrent headaches
    • Migraines


    • Unexplained tiredness or lethargy

Cardiovascular Symptoms:

    • Rapid or irregular heartbeat (tachycardia)
    • Low blood pressure

Central Nervous System Symptoms:

    • Dizziness
    • Difficulty concentrating
    • Anxiety
    • Insomnia
    • Mood swings

High Histamine Foods

It’s important to note that histamine intolerance symptoms often occur after consuming histamine-rich foods or beverages. These can include aged cheeses, processed or fermented foods, alcoholic beverages, as well as certain fruits and vegetables.

High Histamine Foods Include:

    • Alcohol
    • Fermented foods
    • Aged foods
    • Fish and shellfish
    • Bone broth
    • Dairy
    • Grains
    • Avocado
    • Tomato
    • Soy
    • Eggplant
    • Oranges
    • Strawberries
    • Vinegars

Hidden Factors That Worsen Histamine Intolerance

Spike Protein. The spike protein is causing more histamine intolerance than ever before, including an increase in insulin dysregulation (leading to swings in blood sugar independent of food intake), gut issues, CNS, lung issues, and skin issues.

The Spike Protein affects histamines through three separate pathways:

1. There is a dysregulation of the histamine receptor gene (HRH1) that leads to high histamine and exaggerated inflammatory response. This triggers insulin imbalance, and that triggers chronic cortisol release (your stress hormone). As a result, the adrenals become depleted and chronic fatigue sets in.

2. As the Spike Protein turns on the histamine receptor gene HRH1, it intersects with the sulfation pathway, and also intersects with the oxalate metabolism pathway. This disrupts the ability to metabolize and detox foods with sulfur and oxalates.

3. The GABA response through ACE2 receptor inhibition becomes impaired, which also leads to insulin dysregulation and adrenal depletion.

Sulfur. Foods, medication and supplements containing sulfur can worsen the histamine response. Foods with sulfur include broccoli, cauliflower, kale, cabbage, kale, onions, garlic and egg yolks.

Amyloids. Amyloids are found in proteins from chicken, turkey, pork, and conventionally raised beef; they are indigestible and feed the spike protein. The spike protein then produces more amyloids which increase the histamine response.

Oxalates. Oxalate containing foods will put more of a burden on the body as the Spike Protein disrupts the oxalate metabolism even more, and this will worsen the histamine response.

Top 4 Supplements to Lower Histamine Response

Acceleradine® Iodine

In addition to devitalizing foreign pathogens like viruses and bacteria, Acceleradine® Iodine may help to alleviate the side effects from the spike protein, reduce histamines, lessen allergies, and open up the detox pathways that cause histamine intolerance. Additionally, it supports healthy thyroid function and metabolism, increases ATP and mitochondrial health, and hormonal balance – all integral parts of a healthy immune system and efficient histamine response.

Histamine Digest™

This supplement helps digest histamines quickly using a patented DAO enzyme, and helps support healthy histamine levels in the small intestine, colon, uterus, bladder, and prostate, as well as in breast milk.

Accelerated Colloidal Silver™

Accelerated Colloidal Silver™ may help to strengthen the immune system, while also helping to alleviate allergies, histamine response, and inflammation. Accelerated Colloidal Silver™ is enhanced with scalar frequencies to further strengthen the immune system and devitalize foreign pathogens that can trigger negative histamine response.


Naturally occurring, this proteolytic enzyme not only has an anti-inflammatory effect but also helps lessen the histamine response related to the spike protein.

Additional Supplements to Help With Histamine Intolerance

Stress Mover

This supplement contains Manganese, which can help modulate histamine by suppressing mast cell activation. Taurine, another ingredient in Stress Mover, may also play a role in reducing histamine and mast cell activity.


This electrolyte powder is rich in minerals such as sodium, potassium, magnesium, and calcium which are vital for maintaining hydration in the body as well as supporting the detoxification processes, including the breakdown of substances such as histamine.

Immune Mover™

This supplement contains stinging nettle extract, which has histamine balancing mechanisms that can reduce histamine levels, as well as overall inflammation.


The spike protein dysregulates the cortisol (stress hormone) release, depleting the adrenals and disrupting a healthy histamine response. Adrenosen™ is an adrenal glandular that helps support the proper function of the adrenals, for energy and normal histamine response.


The spike protein is causing an impaired GABA response, which then leads to insulin dysregulation and affects the histamine response.


Histamine response is regulated in the gut; MegaSporeBiotic™ helps recondition the gut microbiome, and promotes healthy microbial diversity to support a healthy histamine response.

Accelerated Ancient Salt®

Salt is antihistamine; and both vasopressin and histamine are released when the body is salt deficient. The blood volume lowers when someone is salt deficient, as such, the body goes into survival mode by shutting down selected capillaries to keep blood pressure normal. It does that by releasing vasopressin and histamine. Accelerated Ancient Salt® contains 62 minerals, all of which help balance out the alkalinity in the body, hydrate the inside of the cells, reduce inflammation, and flush out the toxins, parasites, and pathogens that contribute to histamine intolerance.

Accelerated Cellular Detox® Powder

This combination of organic ingredients binds the toxins leading to histamine intolerance, reduces histamine related inflammation in the gut, improves regularity, and helps heal the gut.

Lifestyle Changes to Reduce Histamine Intolerance

    • Eliminate Amyloid Proteins. Amyloid proteins are found in chicken, pork, turkey, and conventionally raised beef. Amyloids contribute to histamine intolerance and strengthen the growth of the Spike Protein in the body, worsening inflammation, gut issues, pathogenic load, and insulin dysregulation.
    • Eliminate Oxalate Foods. These foods include spinach, almonds, berries, kale and most nuts. This will take the burden off the system and lower the histamine response.
    • Eliminate High Histamine Foods. By eliminating the foods listed above, you will lower the histamine burden on the body, allowing the digestive system to heal, insulin to regulate, and histamine intolerance symptoms subside.
Sara Banta

Sara Banta is a Stanford University Graduate with a Degree in Economics and Psychology, and a certified Natural Supplement Expert & Graduate of the Institute for Integrative Nutrition. Sara is the Founder of Accelerated Health Products and host of the health & wellness podcast, Accelerated Health Radio.

sara banta blog

Hi, I’m Sara Banta!
I’m a certified natural supplement expert, podcaster, Health Coach, and natural wellness expert. Each week I publish articles on the latest in cutting-edge health supplements and natural health solutions. I also interview leading experts across a wide range of health topics to transform your body, mind & spirit. I’m also the Founder of Accelerated Health Products. Join my mailing list and receive 10% off your first order.