Uric acid used to only be considered when talking about gout, but there is much more to the story of uric acid; importantly the connection between high uric acid levels and obesity.
Firstly, let’s learn about uric acid.
What is Uric Acid
Uric acid is a waste product and generated during normal metabolism; the body eliminates uric acid mostly through urine, and some remains in the gut where bacteria breaks it down.
The problem arises when levels of uric acid build up in the blood, usually in people who are overweight and/or have prediabetes. When uric acid levels become too high, the uric acid becomes unstable and can crystalize, especially in the joints, and this leads to gout.
Uric Acid and Gout
Traditionally uric acid has always been connected to gout.
Below are the main symptoms associated with high uric acid levels and gout:
1. Gout Attacks. The most common symptom of gout is an acute attack of joint pain, often affecting the big toe. The pain usually comes on suddenly, often during the night, and is accompanied by swelling, redness, and tenderness in the affected joint. Gout attacks can also occur in other joints, such as the ankles, knees, wrists, and fingers.
2. Joint Discomfort. In addition to gout attacks, some people with high uric acid levels may experience ongoing joint discomfort or mild joint pain. This discomfort can persist between gout attacks and may affect multiple joints.
3. Tophi. Tophi are collections of urate crystals that can form under the skin. They appear as small, firm lumps or nodules and are often painless. Tophi most commonly develops in the joints of the fingers, hands, elbows, and ears. Over time, they may grow in size and become more visible.
4. Kidney Stones. In some cases, high uric acid levels can lead to the formation of kidney stones. These stones can cause severe pain in the back or abdomen, blood in the urine, frequent urination, and difficulty passing urine.
Uric Acid: The Cause of More than Just Gout
Research is now questioning which came first: uric acid or insulin resistance.
Before 1980, high uric acid levels were connected to a diet heavy in purine rich food like alcohol, organ meats, and shellfish. And, years ago, most people had sufficient copper in the body to help blunt the rise in uric acid.
Today there is a rapid increase in processed foods full of fructose and stripped of copper. As a result, uric acid levels have skyrocketed, making uric acid the hidden cause of not just gout, but high levels of insulin resistance, non-alcholic fatty liver disease, and obesity.
With the rapid increase in processed foods stripped of fructose and copper, uric acid levels have skyrocketed resulting in gout, high levels of insulin resistance, non alcoholic fatty liver disease and obesity.
Fructose and Uric Acid
Fructose has been shown to cause insulin resistance, elevated blood triglycerides, hypertension, and high uric acids levels. The surprising part is if uric acid is blocked while consuming fructose, then obesity, high triglycerides, and hypertension don’t occur.
In other words, uric acid is what leads to obesity, insulin resistance, high triglycerides, and hypertension.
Another unknown chain reaction:
1. The natural metabolism of Fructose CAUSES massive Copper chelation (Briggs et al, 1981).
2. Low bioavailable copper causes hepatic (or Liver) Iron accumulation that leads to Nonalcoholic Fatty Liver Disease.
3. Low copper causes high triglycerides and cholesterol.
It was once a general belief that fructose metabolized like glucose— once it was broken down, its by-products were utilized for energy that was either used immediately or stored as fat. However, this theory doesn’t explain that when uric acid is blocked, obesity and insulin resistance doesn’t ensue.
Uric acid is biologically active and not just a waste product getting stuck in the joints; it is the key that causes metabolic syndrome and leads to obesity.
Uric acid is biologically active. It is the KEY that causes metabolic syndrome and leads to obesity.
The Polyol Pathway
The Polyol Pathway, also known as the sorbitol-aldose reductase pathway or the sorbitol pathway, is a metabolic pathway that converts glucose to sorbitol and then fructose.
Hyperglycemia, or high blood sugar, triggers the activation of the Polyol Pathway enzyme, Aldose Reductase, to break down fructose.
To make matters worse, fructose consumption deregulates cellular energy by decreasing ATP (the energy in the mitochondria of the cell) and increasing your appetite for more fructose! This, of course, leads to worsened levels of uric acid and obesity. (Cut your sugar cravings forever to reduce your fructose consumption).
The Polyol Pathway and Uric Acid
Converting glucose into sorbitol and fructose via the Polyol Pathway involves a series of enzymatic reactions and is particularly important in certain tissues, such as the lens of the eye, the peripheral nerves, and the kidneys.
As previously mentioned, the key enzyme in the Polyol Pathway is Aldose Reductase.
Aldose Reductase catalyzes the reduction of glucose to sorbitol using NADPH (nicotinamide adenine dinucleotide phosphate) as a cofactor. Sorbitol can then be converted to fructose by the enzyme sorbitol dehydrogenase.
Under normal physiological conditions, the Polyol Pathway is not highly active in most tissues. However, in certain pathological conditions, such as diabetes mellitus, the Polyol Pathway can become overactive. This occurs when there is a high concentration of glucose in the blood, which leads to increased glucose flux through the pathway.
Overactivation of the Polyol Pathway can have several detrimental effects.
1. Firstly, the conversion of glucose to sorbitol consumes NADPH, which can lead to a decrease in the availability of this cofactor for other important cellular processes such as the maintenance of reduced glutathione levels, which is involved in protecting cells against oxidative stress.
2. Secondly, the accumulation of sorbitol and fructose can lead to osmotic stress as these molecules have low permeability across cell membranes. This can result in the influx of water into cells, causing cellular swelling and damage.
3. Finally, the conversion of sorbitol to fructose by sorbitol dehydrogenase generates excessive amounts of reactive oxygen species (ROS), which can promote oxidative stress and contribute to cellular damage.
The activation of the Polyol Pathway and its associated detrimental effects have been implicated in the development of diabetic complications, such as diabetic retinopathy (eye damage), neuropathy (nerve damage), and nephropathy (kidney damage).
While it plays a normal physiological role in certain tissues, its overactivation in conditions like diabetes can lead to the depletion of NADPH, osmotic stress, and oxidative damage, contributing to the development of diabetic complications.
If the amount of fructose can’t get cleared, the liver must resort to the Polyol Pathway which is how and why uric acid rises inside the mitochondria. To make matters worse, copper can stop this from occurring but is severely depleted in the high fructose diet.
The “Survival Switch”
According to the best-selling author of ‘Nature Wants Us To Be Fat’, Dr Richard Johnson, fructose disengages the normal regulation of weight and triggers the “survival switch.”
The “survival switch” is telling our bodies we need to prepare for famine or winter; its purpose is to slow our metabolism while encouraging fat storage and increased caloric consumption all at once.
The “survival switch” is triggered by too much uric acid, causing the following survival mechanisms:
- Increased fat storage. Uric acid from fructose intake causes an increased production and decreased burning of fat. This survival response provides “stored energy and metabolic water” in case of famine.
- Lowered metabolism. As a survival mechanism, the uric acid tells the body to conserve energy when not needed for foraging.
- Lowered ATP and Energy. Unlike the metabolism of glucose or other molecules, fructose causes ATP levels to fall if a lot of fructose is being metabolized. Fructokinase breaks down fructose very rapidly, quickly using up ATP in the process, and this causes the decline. When ATP levels fall in the cell, the body sees it as a threat; it responds by stimulating hunger immediately, leading to increased food intake.
- Increased Oxidative Stress. Uric acid causes oxidative stress to the mitochondria, decreasing energy production, impairing fat burning, and stimulating fat production simultaneously. By inducing oxidative stress to the mitochondria, it further reduces their ability to make ATP, while stimulating the production of fat.Additionally, the oxidative stress caused by uric acid blocks the burning of fatty acids released from stored fat. So, not only do the mitochondria make less ATP, but also the calories that would have been used to make ATP are now being stored as body fat!
When ATP levels fall in the cell, the body treats it like an emergency and responds by increasing hunger immediately. This leads to increased food intake in the hopes it will restore ATP and increase energy. However, because of the ongoing oxidative stress in the mitochondria, the increased calories are converted to fat. To make matters worse, if the food ingested is fructose, it will exacerbate the issue by dropping ATP levels further and creating even more oxidative stress.
- Increased Insulin Resistance. Uric acid makes more glucose available to the brain for fuel during “survival” which increases overall insulin resistance. It does this by using insulin resistance in the muscles throughout the body which then directs the glucose to the brain where less insulin is needed. If the body is under “threat” it is important for the brain to get that energy to be able to “react” quickly to the threat. Furthermore, increased fructose intake over time will increase insulin resistance even more.
- Increased Leptin Resistance. Normally when you consume calories from protein, fat, and even glucose, the hormone Leptin will tell the brain to stop eating; fructose causes the brain to seek out even more fructose and increases the appetite, overriding the normal signaling. Fructose causes Leptin Resistance for survival so that the body is able to store excess fat to prepare for famine.
- Increased Appetite through Dopamine. Fructose increases dopamine signaling initially like a drug, and getting the brain hooked on wanting more. After time, that dopamine level comes down, causing the craving for more fructose to get the same initial dopamine “hit”.
- High Blood Pressure. Uric acid raises your blood pressure to keep the circulation strong for survival.
- Increases Inflammation. Inflammation is essential when the body is threatened. Fructose and uric acid increase inflammation throughout the body to fight off possible infections.
The PAM Enzyme and Uric Acid
The key to clearing rising blood sugars is the optimal function of the PAM Enzyme (Peptidyl-glycine alpha-amidating monooxygenase) to activate a cascade, signaling peptides and hormones at the pancreas, gut and organs, to get sugars INSIDE the tissue and cells.
These include, but are not limited to:
- Chromogranin A (CgA)
- Incretin (GLP-1)
What is the missing key to optimizing PAM function? Copper.
How to Reduce Uric Acid Levels to Reverse Obesity
- Drink plenty of water. Staying well-hydrated helps dilute uric acid and promotes its excretion from the body. Aim for at least 8-10 cups of water per day.
- Eliminate Processed Foods and Fructose. High Fructose Corn syrup and processed foods significantly increase uric acid, and deplete copper which leads to fatty liver, insulin resistance, and obesity.
- Limit Alcohol. Alcohol, particularly beer, is associated with increased uric acid levels and fatty liver. The high level of purines in alcohol lead to high levels of uric acid. Read about the damaging effects of alcohol and how to start reversing the damage.
Essential Supplements to Help Lower Uric Acid Levels
The above lifestyle changes will help but are generally not enough to reduce uric acid levels affecting weight gain. The following supplements have a significant impact on reducing uric acid levels in addition to helping with fat loss.
Accelerated Scalar Copper™
Accelerated Scalar Copper™ is the only copper supplement with 100% absorption (vs 5-10% in other supplements), made with proprietary scalar technology and enhanced with frequencies for increased efficacy.
Copper helps decrease uric acid and obesity through multiple different ways:
Copper blocks the Polyol Pathway which is responsible for converting glucose into sorbitol and fructose. Because of this mechanism, Uric Acid stays in check and fat gain and obesity is prevented.
Without copper, not only does uric acid and fat gain increase, but triglycerides and liver fat increases; fatty liver and triglycerides are what lead to obesity.
- The body cannot metabolize fat without copper.
- Copper inhibits PDE3 enzyme which is an enzyme that blocks fat burning; if the body can’t block PDE3, then it can’t burn fat.
- Low levels of cellular copper make fat cells “fatter” by altering how they process their main metabolic fuels, such as fat and sugar.
- Copper helps increase fat burning mechanisms.
- Copper helps regulate iron in the blood which is the root cause of oxidative stress. With less oxidative stress, there is less uric acid.
Uric acid buildup is partly due to the liver getting overloaded. Acceleradine® Iodine helps cleanse the liver and the blood, alleviating the liver back up caused by uric acid. Furthermore, Acceleradine® Iodine increases metabolism and fat oxidation, lowers blood sugar, regulates hormones, and hydrates the cells – all factors that help reverse high uric acid and obesity.
Acceleradine® is the only monatomic and radiation-free iodine that has 100% absorption and is enhanced with scalar frequencies to detox the cells from heavy metals and radiation in all 100 trillion cells in the body. It helps reverse the damage done to the DNA by the Spike Protein.
Accelerated Ancient Salt™
Accelerated Ancient Salt™ plumps up the blood to flush out the toxins, hydrate the cells, support apoptosis, break down the fats in the liver, improve digestion, and dilute the uric acid.
It provides over 62 minerals and is free of toxins, which helps INTRACELLULAR hydration; this is in stark contrast to most salts that are only sodium and full of microplastics which cause inflammation.
Additional Supplements that Help Reduce Uric Acid Levels & Weight Loss
Research has shown that it’s possible 9 out of 10 people suffer from suboptimal thyroid function which contributes to fat gain, lethargy, and water retention. Accelerated Thyroid® not only increases metabolism and fat burning, but also helps reverse fatigue, hypothyroidism, and toxicity in the thyroid. These mechanisms help encourage the reversal of obesity.
Liver Flush Cleanse
The liver is responsible for fat metabolism, optimal thyroid function, and optimal detoxification— all factors that contribute to reversing insulin resistance, fatty liver, and weight loss. The supplements in the Liver Flush Cleanse soften liver stones and prep the liver to release those stones into the toilet! As a result, detoxification, fat burning, and metabolic rate increase.
With hundreds of stones sitting in your liver, it isn’t able to break down fats for usable energy, to detox the body of toxins that cause bloat and weight gain.
The Liver Flush Cleanse also helps to:
- Improve the breakdown of protein and fats
- Eliminates pain, cramps, and inflammation
- Helps lower AST and ALT liver enzyme counts
- Replaces damaged liver cells with healthy ones
- Reverses fatty liver disease
- Eliminates thousands of toxins and pollutants
- Reduces Uric Acid
- Flushes out unhealthy cholesterol deposits
- Opens obstructions in the liver and gallbladder
- Boosts the immune system
- Allows the liver and gallbladder to regenerate.
Accelerated Keto™ flips the body into ketosis and fat burning mode which helps reduce uric acid and obesity in a few different ways:
- The additional ingredients in Accelerated Keto™ turn the saturated liver fat into unsaturated fat which is easier to burn and utilize. This expedites the decreased liver fat and, in turn, reduces insulin resistance and uric acid.
- It suppresses cravings for sugar, fructose and processed foods; these are the foods that increase uric acid, insulin resistance, fatty liver, and fat gain.
- It reduces inflammation and oxidative stress throughout the body, and both of those increase uric acid and insulin resistance.
- It teaches the body to burn its own fat stores efficiently and quickly while maintaining healthy muscle.
Sara Banta is a Stanford University Graduate with a Degree in Economics and Psychology, and a certified Natural Supplement Expert & Graduate of the Institute for Integrative Nutrition. Sara is the Founder of Accelerated Health Products and host of the health & wellness podcast, Accelerated Health Radio.