Autophagy is a term that has become very popular lately and for good reason. It is a biological process that removes the body’s accumulated toxins and recycles damaged cell components.
The term autophagy means “self-eating,” where cells use their own components to rebuild new cells. It is activated primarily when you are experiencing energy deprivation or exercise. It is stimulated by lowering insulin and a ketogenic diet, and it helps combat Free Radicals.
First, understanding “Autophagy” means understanding “Free Radicals.”
What is a Free Radical?
A free radical is an atom or molecule with a single unpaired electron in its outer layer. Most free radicals are very reactive and cause oxidative damage. That oxidation can be lowered by antioxidants and other reducing agents. Mitochondria are the cell’s energy manufacturers that generate ATP, also known as adenosine triphosphate. This is true cellular energy.
This process occurs by reacting hydrocarbons from calories or sunlight with oxygen. The classical Free Radical Theory of Aging proposes that energy generation by the mitochondria damages mitochondria macromolecules, including mitochondrial DNA which then promotes aging. After a certain amount, this produces too many reactive oxygen species (ROS), which causes cell death and degradation.
Age-related impairments in the mitochondrial respiratory chain decrease ATP synthesis, damage DNA, and make these cells more susceptible to oxidative stress.
How Does Hormesis Increase Autophagy?
Hormesis is a serving-specific response to a toxin or a stressor that makes the organism stronger than it was before. The idea is that you experience a small shock that makes the body want to deal with it better in the future and become more resilient. Examples of hormetic stressors include caloric restriction, intermittent fasting, exercise, and dietary phytonutrients.
Factors that Inhibit Autophagy and Induce Mitochondrial Aging
1. Insulin and High Glucose
Insulin and glucose environments generate free radicals and promote oxidative stress and inflammation. The insulin signaling pathway is one of the main mechanisms of accelerated aging.
2. Chronic Stress
Overproduction of free radicals because of too many stress hormones decreases mitochondrial functioning, accelerates aging, and makes you prone to disease due to a weakened immune system, high insulin, and damage to cells.
3. Sleep Deprivation and Circadian Mismatches
If your body’s biological clock is misaligned with its circadian rhythms, then you’ll cause more cellular stress and predispose yourself to all types of dysfunctions.
4. Environmental Toxins and Pollution
Polluted air, water, heavy metal exposure, mercury and food, pesticides, glyphosate, GMO crops, toxic personal care products, and house cleaning chemicals will create more reactive oxygen species and oxidative stress. The amount of these stressors is beyond our body’s natural ability to cope with them.
Inflammation is correlated with most diseases, as it directly decreases the body’s immune system. Processed foods and overcooked food increase the number of free radicals and carcinogens in addition to increasing inflammation.
Benefits of Autophagy
There are many health benefits from Autophagy including the following:
1. Regenerates Aging Cells and triggers Anti-Aging Mechanisms
2. Increases Detoxification of Heavy Metals, Toxins, Poisons, and Radiation
3. Boosts the Immune System
4. Cleans internal cellular machinery
5. Cleans up mitochondria through a process called Mitophagy
6. Reverses Insulin Resistance
7. Increases Growth Hormone and Testosterone
8. Maintains muscle mass which is associated with longevity
9. Eliminates Skin Sag for those who have lost weight and have loose skin
10. Accelerates recovery from Traumatic Brain Injuries
11. Reverses or slows down the progression of Alzheimer’s or Dementia
12. Increases the number of cells that are turned over in a short period
13. Cellular breakdown and protein breakdown to then be recycled.
14. Suppresses MTOR
15. Improves Circadian Rhythm and Sleep
What Prevents Autophagy from Triggering?
1. Not Fasting Long Enough
In general, food is in your stomach for about 4.5 hours. Most people count their fasting window from the time they stop eating when you should be counting from 5 hours after you eat.
2. Drinking fatty coffee
Even though the added fat to the coffee doesn’t stimulate insulin, it still puts you in a “fed” state as you are consuming calories. Ketone bodies stimulate autophagy. Excess calories whether they come from MCT oil or other fats will stop autophagy.
3. Supplementing with BCAAs or Branched Chain Amino Acids
These will kick you out of ketosis and halt autophagy. They can be beneficial to take during exercise to build muscle.
4. Consuming Artificial Sweeteners
Most fake sweeteners will raise insulin. Aspartame, Saccharin, and agave will all create an insulin response that immediately turns off autophagy. Stevia and xylitol have a much less effect on insulin, if any.
5. Consuming Supplements with Calories
If you are taking a lot of supplements, then the calories will add up. Normally this isn’t any issue, but you can always take supplements during your “fed” state to be sure.
6. Circadian Rhythms
HGH and autophagy spike between 11 pm-2 am. Those are the most important hours of sleep to increase repair and autophagy. Don’t miss the window.
7. Not Doing Prolonged Fast
You need to do it longer than 24 hours to trigger autophagy. A 72-hour fast will achieve the highest level of autophagy.
8. Doing Too Many Prolonged Fasts Too Often
If you are losing muscle then you will know, and the benefits of fasting become outweighed by the negative effects.
9. Not Consuming Sufficient Nutrients and Minerals
It is important to get wild organic proteins, minerals, and electrolytes so the body is strong enough to gain the benefits of autophagy.
10. Not Exercising
Exercise promotes autophagy, mobilizes fat oxidation, and keeps insulin and blood sugar low.
Supplements to Trigger Autophagy
Lifewave X39 patches activate a peptide called GHK to increase your stem cell production and reset 4000 genes to younger state. As a result, it helps repair collagen in all tissues, activates stem cell production, encourages apoptosis of cancer cells, and discourages metastatic cancer cells.
The copper peptide will increase the ability of stem cells to get to an injury site. It will also revert stem cells to pluripotent stem cells and increase the number of stem cells circulating in the body. Through clinical studies, an improvement in the body’s overall energy, organ balance, and symmetry distribution of energy was improved as well. The increase in stem cells occurs within 24 hours of using the X39 patch and most people feel a difference within the first 7 days.
This is not Vitamin C, but rather ESS Carbon 60. A study involving rats showed that an ESS60 supplement could increase lifespan up to 90 percent compared to the control group. They found that ESS60 is a very powerful antioxidant and fights against the negative effects of free radicals and oxidative stress by essentially operating under a “free radical scavenging mechanism”.
It may also help stop cancer cells from mass-producing tumors and may halt tumor growth.
What’s more, the ESS60 was shown to protect the liver. Because it aids in cell growth and strengthens vital body systems, and it is a potent antioxidant, protecting cells against free radicals, it has been shown to increase lifespan.
Because ESS60 reduces oxidative stress, it inhibits TNFalpha and IL-1, which are both responsible for inflammation in the body. This includes joint inflammation; the molecular structure of ESS60 in olive oil has been shown to help reduce the inflammation associated with arthritis and other joint disorders.
MyVitalC improves sleep which is essential for longevity; a lack of sleep causes oxidative stress and insufficient repair within the body. It has been shown to help regenerate new neurons that may help reverse brain diseases including dementia and Alzheimer’s. It helps with strengthening cartilage and bones and increasing hair growth.
Ascent Diet Cleanse
This comprehensive cleanse incorporates Accelerated Keto®™, Acceleradine®, Accelerated Silver®, Accelerated Cellular Detox Powder®, and supplements to help flush gallstones and liver stones out of the body safely. The synergistic combination increases ATP production and efficacy, increases mitophagy, autophagy, thyroid health, metabolism, mental clarity, physical energy, endurance, and anti-inflammatory mechanisms.
As a result, clients lose body fat, especially the dangerous visceral fat that is connected to chronic disease, increasing the cells’ phase angle or the cells’ ability to absorb nutrients and release toxins that affect ATP production, while improving mental and physical energy.
The video below features recent testimonials from customers who have completed the Accelerated Ascent Diet Cleanse. Well worth watching if you have considered participating in this transformation program.
Accelerated Colloidal Silver™
Accelerated Colloidal Silver™ is enhancing your immune system’s ability to devitalize foreign pathogens. If your immune system is bombarded with fighting foreign pathogens, it can’t simultaneously engage in anti-aging mechanisms. By keeping the immune system strong, the body engages in anti-inflammatory processes, leading to longevity.
Ketosis and ketone bodies like BHB Promote Sirtuin Activity. Sirtuin activity is associated with autophagy. A Ketogenic diet increases brown fat and improves mitochondrial function; it also promotes sirtuin activity because of the low levels of insulin and glucose.
Accelerated Keto®™ flips you into ketosis within 30 minutes. When the body switches from utilizing glucose for energy to using ketones from fat, autophagy becomes activated, the toxic waste produced minimizes, the inflammation reduces significantly, and the oxidative stress decreases immensely.
Glucose is inflammatory to the brain and all of the tissues in the body. Accelerated Keto®™ gives the brain and body a new fuel system that can actually regenerate old cells through autophagy and by fueling cells that are resistant to glucose and subsequently dying.
Furthermore, ATP production in the mitochondria of the cells increases, which in true cellular energy; with increased ATP and cellular energy, the cells are able to regenerate and recycle more efficiently, including the stem cells.
The additional ingredients in the Accelerated Keto®™ break down saturated fats into unsaturated fats. These unsaturated fats are easier for the body to utilize and easier for the body to convert to ketones. Because of this property, Accelerated Keto®™ can de-fat the liver as well.
It is well known that the liver is responsible for converting stored fat into ketones. The more a person’s liver is defatted and unclogged, the easier it is for the liver to function in all areas including producing ketones, detoxing the bombardment of toxins and radiation from the body that are responsible for accelerated aging, and increasing fat oxidation from the visceral fat and liver fat– two areas that are connected to morbidity.
The liver is also where the thyroid hormone converts from T4 to T3, and as the liver function becomes better, the thyroid works better as well, increasing metabolism and energy further.
Acceleradine® works via healthy apoptosis for DNA repair from mRNA damage as well as stabilizing the DNA. Acceleradine® also works via its negative charge to neutralize the inherent positive magnetic charge of all toxins, including graphene oxide, spike proteins, aluminum, and radiation.
Acceleradine® is the only monatomic iodine with 100% absorption and charged with Scalar frequencies to detox from heavy metals and radiation. It is those toxins that halt autophagy and accelerate aging. Acceleradine® also increases the number of ATP in the cell from 2 to 36; ATP is true cellular energy. When ATP increases, your energy and metabolism increase as well as the activation of autophagy on a cellular level.
Accelerated Ancient Salt™
Accelerated Ancient Salt™ helps restore normal body fluids (rehydration) and also supports any detox symptoms that arise. It is the only Salt that is free of micro-plastics and enhanced with Scalar frequencies to detox from radiation and heavy metals. Furthermore, it provides over 62 minerals needed for the electricity within the cells and for the sodium-potassium pump to function properly.
This perfect isotonic solution of organic ocean minerals is diluted with natural alpine spring water to achieve the same consistency as your blood plasma. It supports homeostasis, rehydration and contributes to normal digestion. This 0.9 concentration can help replenish mineral and trace element levels, gently detoxify, and support sleep, relaxation, and digestion.
Accelerated Cellular Detox Powder®
The negative charge of the detox powder and the combination of the six organic ingredients soak up the toxins and poisons that contribute to oxidative stress and inflammation. The daily “clean up” of radiation, heavy metals, GMOs, pesticides, and poisons is essential for increasing longevity.
Nucnomore® eliminates all non-ionizing radiation and ionizing radiation. Radiation not only causes an increased risk of cancer, thyroid disease, and other chronic diseases but also degrades the health of the cells which leads to accelerated aging. This is the only supplement able to zero out radiation from the body.
The liver is the master organ for detoxification. If the liver is functioning suboptimally, toxins will build up, trigger inflammation, activate mechanisms to shorten telomeres, and stunt the effects of stem cells.
Y-age Glutathione Patches
Glutathione is the master antioxidant, detoxifier, immune booster, and neuroprotector. It increases glutathione by 300% in 24 hours. When it is worn with X39, glutathione production increases to 400%. Additionally, it is Antiviral and great for infections. For chronic issues, it brings glutathione levels up so suffering goes down in symptoms like autoimmune issues, arthritis, autism, MS, and Parkinson’s.
There is a direct correlation between high levels of glutathione and longevity. The glutathione patch signals the body to make its own glutathione; it is not transdermal glutathione.
Energy Enhancer Patches
These increase ATP production in the mitochondria, increase Heart Rate Variability, improve the bioelectrical measurement or “phase angle” or integrity of the cell walls, reduce inflammation, and increase endurance. Just after 20 minutes, the capacity of each cell increases.
With age, the cell walls become rigid and hard to penetrate with nutrients coming in and toxins going out. The Energy Enhancer Patches soften that cell wall and improve that phase angle within five minutes of applying the patch.
Additionally, it improves digestion and circulation which are essential for nutrient absorption that leads to improved energy. Lastly, it increases beta-oxidation which is the fastest way to increase cellular energy. As a plus, it increases fat-burning and muscle growth. They work synergistically with Accelerated Keto®™ to enhance fat burning and tap into an endless supply of fuel sources within the body.
Carnosine is a naturally occurring antioxidant in the body, of which production declines with age. Studies on carnosine show that it plays a vital role in overall health, neuroprotection, and anti-aging. In clinical studies, carnosine has also been shown to improve flexibility, strength, balance, and endurance. For athletes, it has been shown to blunt the lactic acid effect that slows muscle and endurance progress.
The Lifewave Y-Age Aeon patch is known as the “Happy Patch”. It increases SOD antioxidants in the body and is turning on our innate immune system. It puts you into the parasympathetic state so you are not constantly in the sympathetic state of “fight or flight”.
Benefits of the Aeon patches include:
- stress reduction
- healthy inflammatory response
- reduction of cortisol & C reactive proteins
- elevation of DHEA
- calm sense of well-being
- increased energy
Wearing an Aeon Patch is like eating 30 cups of royal jelly a day which is connected to increasing longevity.
Other ways to naturally trigger autophagy
Sleep is imperative for cellular health and repair and for triggering autophagy. Without proper sleep, aging is accelerated, and physical and mental energy suffer. It is proven that sleep increases testosterone and human growth hormone which are directly related to anti-aging, improved energy, and increased ATP production.
Everyone needs between 7-9 hours of sleep; no one is exempt from this requirement.
Cold exposure is hormetic stress that increases short-term adrenaline and cortisol to give you a boost in short-term energy. This type of hormetic stress strengthens the immune system, encourages autophagy, and increases longevity.
High-Intensity Interval Training increases testosterone, human growth hormone, autophagy, and ATP production at a cellular level.
It is a misnomer that you need less protein as you age. Your ability to break down and absorb the amino acids decreases, and you actually need more protein to maintain muscle mass. Muscle mass is correlated to longevity. The goal is to prioritize wild animal protein in your diet, fill in with vegetables that work with your DNA, and include healthy fats according to your weight goals.
The AmpCoil system utilizes sound technology combined with biofeedback and an electromagnetic coil to deliver sound frequencies that harmonize, balance, and support you on your journey to wellness. By bringing balance to your body, detoxing from toxins and pathogens, and boosting the immune system, you will inherently increase longevity.
Coffee actually doubles your ketone level and can enhance anti-aging mechanisms. But do not put milk or cream in your coffee; milk or cream will spike insulin and stop autophagy; furthermore, dairy is an allergen for most people and causes inflammation.
Strength training activates autophagy and reduces apoptosis of muscle cells by modulating IGF-1 and its receptors. More muscle will make you more metabolically flexible.
Increased muscle mass is directly related to longevity, and the best way to achieve that is to lift heavy weights till failure. Lifting heavier weights not only builds muscle mass more effectively, but it also stimulates higher levels of growth hormone and testosterone.
Hormetic stress is the type of stress that is a “serving-response” phenomenon characterized by low serving stimulation and high-serving inhibition. These stressors are known to increase longevity, activate autophagy, boost the immune system, and optimize overall health.
Diminishing Chronic Stressors
Chronic stress from life, finances, anxiety, fear, and more will not only lower your immune system and weaken stem cells, but it will also increase cortisol, which increases insulin, and that in turn increases oxidative stress and shortens telomeres. Stress truly does shorten life quicker than any other lifestyle factor.
A study showed that sustained lower food intake over time results in an increase of telomere length and the ends of the chromosomes which has a protective effect on the DNA and genetic material.
This was connected with a lower incidence of cancer and other age-related illnesses. Furthermore, caloric restriction and energy deprivation lower mTOR signaling, which in turn upregulates other pathways of energy homeostasis, such as AMPK and autophagy.
Vitamin D and Sunlight
Low levels of Vitamin D inhibit autophagy. Both Vitamin D and autophagy are important for lower inflammation.
Fasted cardio does induce higher levels of autophagy. By engaging in cardio exercise while fasting, you are increasing your level of ketosis and autophagy. This turns on your anti-aging mechanisms, increases growth hormone, and testosterone.
All you need is just 30 minutes of low-intensity cardio to increase it; chronic long cardio sessions will backfire and accelerate aging.
An Infrared Sauna induces heat shock proteins. This fights free radicals, repairs damaged proteins, boosts growth hormone, improves stress adaptation, increases lifespan, increases autophagy, increases detoxification, increases ATP production, balances hormones, and increases energy. All of these results encourage longevity.
Substances like coffee, medicinal mushrooms, apple cider vinegar, herbal teas, cruciferous vegetables, turmeric, ginger won’t put you into a state of autophagy by themselves but will increase the level of autophagy by depleting your cells of energy.
72-hour fasts will increase the production of stem cells and achieves the maximum amount of autophagy. The fat-burning effect of fasting spurs the stem cells. Also, something called PKA is a gene that needs to be shut down for stem cells to spread and go to work. Fasting lowers this PKA to further the activity of stem cells in the body. Furthermore, fasting helps lengthen telomeres.
There is an enzyme called telomerase that can re-lengthen telomeres that are shortened during DNA replication. During extended fasting, the body produces “hematopoietic Stem Cells” that encourage more stem cell production, and when you begin the “refeeding” state, your body triggers a mass amount of strong daughter stem cells to be produced.
Low Carb Diet
Carbohydrates are what cause inflammation, and oxidative stress throughout the body. A high-carb diet is connected to many metabolic diseases including diabetes, insulin resistance, obesity, heart disease, thyroid disease. By staying on a Low Carb diet, insulin and blood sugar remain low and make it easier for the body to trigger autophagy and produce ketones.
Sara Banta is a Stanford University Graduate with a Degree in Economics and Psychology, and a certified Natural Supplement Expert & Graduate of the Institute for Integrative Nutrition. Sara is the Founder of Accelerated Health Products and host of the health & wellness podcast, Accelerated Health Radio.